publications

Epigenomic analysis of primary human T cells reveals enhancers associated with TH2 memory cell differentiation and asthma susceptibility.

Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice.

  • Watchmaker PB, Lahl K, Lee M, Baumjohann D, Morton J, Kim SJ, Zeng R, Dent A, Ansel KM, Diamond B, Hadeiba H, Butcher EC.
    Nat Immunol. 2014 Jan;15(1):98-108. December 1, 2013

The microRNA cluster miR-17∼92 promotes TFH cell differentiation and represses subset-inappropriate gene expression.

  • Baumjohann D, Kageyama R, Clingan JM, Morar MM, Patel S, de Kouchkovsky D, Bannard O, Bluestone JA, Matloubian M, Ansel KM, Jeker LT.
    Nat Immunol. 2013 Aug;14(8):840-8. June 30, 2013

Persistent Antigen and Germinal Center B Cells Sustain T Follicular Helper Cell Responses and Phenotype.

T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire

  • Bronevetsky Y, Villarino AV, Eisley CJ, Barbeau R, Barczak AJ, Heinz GA, Kremmer E, Heissmeyer V, McManus MT, Erle DJ, Rao A, Ansel KM
    J Exp Med. 2013 Feb 11;210(2):417-32. February 4, 2013

Eri1 degrades the stem-loop of oligouridylated histone mRNAs to induce replication-dependent decay.

An integrated nano-scale approach to profile miRNAs in limited clinical samples

  • Seumois G, Vijayanand P, Eisley CJ, Omran N, Kalinke L, North M, Ganesan AP, Simpson LJ, Hunkapiller N, Moltzahn F, Woodruff PG, Fahy JV, Erle DJ, Djukanovic R, Blelloch R, Ansel KM
    Am J Clin Exp Immunol. 2012 Nov 30;1(2):70-89 November 30, 2012

Airway Epithelial miRNA Expression Is Altered in Asthma.

Eri1 regulates microRNA homeostasis and mouse lymphocyte development and anti-viral function

Interleukin-4 Production by Follicular Helper T Cells Requires the Conserved Il4 Enhancer Hypersensitivity Site V

  • Vijayanand P, Seumois G, Simpson LJ, Abdul-Wajid S, Baumjohann D, Panduro M, Huang X, Interlandi J, Djuretic IM, Brown DR, Sharpe AH, Rao A, Ansel KM
    Immunity. 2012 Feb 9;36(2):175-87. February 9, 2012

MicroRNA-29 Regulates T-Box Transcription Factors and Interferon-γ Production in Helper T Cells.

Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems.

  • Parameswaran P, Sklan E, Wilkins C, Burgon T, Samuel MA, Lu R, Ansel KM, Heissmeyer V, Einav S, Jackson W, Doukas T, Paranjape S, Polacek C, dos Santos FB, Jalili R, Babrzadeh F, Gharizadeh B, Grimm D, Kay M, Koike S, Sarnow P, Ronaghi M, Ding SW, Harris E, Chow M, Diamond MS, Kirkegaard K, Glenn JS, Fire AZ.
    PLoS Pathog. 2010 Feb 12;6(2):e1000764. February 12, 2010

Mouse Eri1 interacts with the ribosome and catalyzes 5.8S rRNA processing.

  • Ansel KM, Pastor WA, Rath N, Lapan AD, Glasmacher E, Wolf C, Smith LC, Papadopoulou N, Lamperti ED, Tahiliani M, Ellwart JW, Shi Y, Kremmer E, Rao A, Heissmeyer V.
    Nat Struct Mol Biol. 2008 May;15(5):523-30. April 27, 2008

The NFAT1 transcription factor is a repressor of cyclin A2 gene expression.

Regulation of the germinal center response by microRNA-155.

  • Thai TH, Calado DP, Casola S, Ansel KM, Xiao C, Xue Y, Murphy A, Frendewey D, Valenzuela D, Kutok JL, Schmidt-Supprian M, Rajewsky N, Yancopoulos G, Rao A, Rajewsky K.
    Science. 2007 Apr 27;316(5824):604-8. April 27, 2007

MicroRNA profiling of the murine hematopoietic system.

  • Monticelli S, Ansel KM, Xiao C, Socci ND, Krichevsky AM, Thai TH, Rajewsky N, Marks DS, Sander C, Rajewsky K, Rao A, Kosik KS.
    Genome Biol. 2005;6(8):R71. August 1, 2005

Aberrant T cell differentiation in the absence of Dicer.

A plague of autoantibodies.

Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity.

  • Ansel KM, Greenwald RJ, Agarwal S, Bassing CH, Monticelli S, Interlandi J, Djuretic IM, Lee DU, Sharpe AH, Alt FW, Rao A.
    Nat Immunol. 2004 Dec;5(12):1251-9. October 31, 2004

Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5.

Traffic patterns of B cells and plasma cells.

Follicular stromal cells and lymphocyte homing to follicles.

A chemokine-driven positive feedback loop organizes lymphoid follicles.

Chemokines and B-cell homing to follicles.